The first dose of a new preventive treatment was given to close contacts of people affected by leprosy in the two study districts Chandauli and Fatehpur.

The Stop the Transmission of Leprosy! Project

The Stop the Transmission of Leprosy! Project, focuses on early detection of leprosy and preventive treatment of people who have frequent and close contact with persons affected by leprosy. The project aims to reach a total of around 800,000+ contacts of persons already diagnosed with leprosy in India, Indonesia and Brazil. Of all new leprosy patients, 80% occur in these three countries together. The project is funded by the Dutch Postcode Lottery through its Dream Fund. Duane Hinders, Programme Manager NLR, emphasizes the importance: “We are fighting an age-old infectious disease in high-endemic regions in the middle of this COVID-19 pandemic, which is also very much present in the districts we operate in. It is critical to take advantage of the heightened awareness of public health among persons in these communities to reduce both conditions.”

Enhanced preventive regimen (PEP++)

The project, designed by NLR in collaboration with national stakeholders, aims to stop the transmission of leprosy by using a package of innovative tools and best practices. Among them, enhanced preventive medication, called PEP++. The medication will be administered to a random sample of close contacts in multiple doses. These people are more likely to harbour a higher number of leprosy bacilli than the general population or may be infected without any visible symptoms yet.

The current preventive regimen, called SDR-PEP, reduces the risk of leprosy among contacts of new patients by 57%. With the new PEP++ regimen, contacts will receive three doses with a combination of rifampicin and clarithromycin. With this, it is expected that the treatment will be 80-90% effective resulting in a drop of annual new patients within project areas by 50% at the end of the five-year project.

Ceremonial first dose in Chandauli and Fatehpur

In each country, two high-endemic districts or municipalities have been selected. In these districts, mapping of the population at risk of contracting leprosy and perception studies about attitudes and practices towards the disease have already been conducted. In India these are Chandauli and Fatehpur in Uttar Pradesh state. The first contacts will start the new preventive treatment soon after the launch meeting. To reflect on this unique moment, on October 2 2020, in Chandauli and Fatehpur, we celebrate the starting point of what we expect to be a successful strategy to end leprosy transmission. “In its quest to contribute to achieve zero leprosy transmission, NLR is happy to conduct the multi-country PEP++ study in partnership with a wide range of governmental, university and social stakeholders in India”, says Mr. Jan van Berkel (CEO NLR).

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